Groundbreaking Discoveries in Immune System Research Earn Nobel Prize

American scientists Mary Brunkow and Fred Ramsdell, alongside Shimon Sakaguchi from Japan, have been awarded the 2025 Nobel Prize in Physiology or Medicine. Their pioneering work sheds light on peripheral immune tolerance, a process crucial for preventing harmful attacks on healthy cells by the immune system.

The esteemed Nobel Assembly at Sweden's Karolinska Institute honored their research, which has significant implications for developing treatments for autoimmune diseases and cancer. The scientists discovered regulatory T cells, the immune system's 'security guards,' which maintain balance and prevent the immune system from attacking the body's own cells.

Selected by expert committees, the Nobel Prizes recognize outstanding achievements, with the Physiology or Medicine prize traditionally opening the Nobel season. Established by Alfred Nobel, these globally prestigious awards continue to inspire groundbreaking advancements across science, literature, and peace.

(With inputs from agencies.)